Cofilin Antikörper (pSer24) (AbBy Fluor® 350)

Produktnummer ABIN1693313

Der Kaninchen Polyklonal Anti-Cofilin-Antikörper wurde für IF (cc) und IF (p) validiert. Er ist geeignet, Cofilin in Proben von Ratte zu detektieren.

Kurzübersicht für Cofilin Antikörper (pSer24) (AbBy Fluor® 350) (ABIN1693313)

Target: Cofilin (CFL1) (Cofilin 1 (CFL1))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cofilin Antikörper ist konjugiert mit AbBy Fluor® 350

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-Cofilin Antikörper (AbBy Fluor® 350)

Bindungsspezifität: pSer24

Kreuzreaktivität: Ratte

Homologie: Human,Mouse,Dog,Cow,Pig,Chicken,Guinea Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human CFL1/CFL2 around the phosphorylation site of Ser24

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Cofilin

Target: Cofilin (CFL1) (Cofilin 1 (CFL1))

Andere Bezeichnung: Cofilin

Hintergrund:

Synonyms: Cofilin/CFL1 Ser24, 18 kDa phosphoprotein, CFL 1, CFL, CFL1, Cofilin 1, Cofilin 1 non muscle, Cofilin non muscle isoform, p18, COF1_HUMAN.

Background: The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH -dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH -dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.

Gen-ID: 1072

Pathways: Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus, CXCR4-mediated Signaling Events