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NGEF Antikörper (pTyr179) (Alexa Fluor 350)

NGEF Reaktivität: Human, Maus, Ratte IF (cc), IF (p) Wirt: Kaninchen Polyclonal Alexa Fluor 350
Produktnummer ABIN1693212
$438.15
Zzgl. Versandkosten $45.00
100 μL
Lieferung in 11 bis 16 Werktagen
  • Target Alle NGEF Antikörper anzeigen
    NGEF (Neuronal Guanine Nucleotide Exchange Factor (NGEF))
    Bindungsspezifität
    • 15
    • 14
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr179
    Reaktivität
    Human, Maus, Ratte
    Wirt
    • 41
    • 1
    Kaninchen
    Klonalität
    • 41
    • 1
    Polyklonal
    Konjugat
    • 10
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser NGEF Antikörper ist konjugiert mit Alexa Fluor 350
    Applikation
    • 25
    • 25
    • 13
    • 8
    • 6
    • 6
    • 3
    • 2
    • 2
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Chicken
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic phosphopeptide derived from human Ephexin-1 around the phosphorylation site of Tyr179
    Isotyp
    IgG
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C/-80 °C
    Informationen zur Lagerung
    Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles
    Haltbarkeit
    12 months
  • Target
    NGEF (Neuronal Guanine Nucleotide Exchange Factor (NGEF))
    Andere Bezeichnung
    Ephexin-1 (NGEF Produkte)
    Synonyme
    Ephexin-1, ARHGEF27, EPHEXIN, Tims2, ephexin, Besh3, ephexin-1, neuronal guanine nucleotide exchange factor, NGEF, Ngef
    Hintergrund

    EPHEXIN is a 710 amino acid protein that localizes to both the membrane and the cytoplasm and contains one SH3 domain, one PH domain and one DH domain. Expressed at high levels in brain and present at lower levels in lung tissue, EPHEXIN interacts with EphA4 and functions as a guanine nucleotide exchange factor (GEF) that is capable of activating Rho A, Rac 1 and Cdc42 and is thought to play a role in axon guidance and growth cone collapse. EPHEXIN is subject to Src-dependent phosphorylation, an event that increases the GEF activity of EPHEXIN toward Rho A. Human EPHEXIN, which exists as multiple alternatively spliced isoforms, shares a high degree of sequence homology with its mouse counterpart, suggesting a conserved role between species.

    Subcellular location: Cytoplasm, Cell membrane

    Synonyms: Ephexin-1 phospho Y179, p-Ephexin-1 phospho Y179, ARHGEF27, Eph-interacting exchange protein, EPHEXIN, Ephexin 1, Neuronal guanine nucleotide exchange factor, Ngef, NGEF_HUMAN.

    Gen-ID
    25791
    Pathways
    Neurotrophin Signalübertragung
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