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Allergin-1 Antikörper (AA 61-160) (Alexa Fluor 350)

MILR1 Reaktivität: Human IF (cc), IF (p) Wirt: Kaninchen Polyclonal Alexa Fluor 350
Produktnummer ABIN1692930
$438.15
Zzgl. Versandkosten $45.00
100 μL
Lieferung in 11 bis 16 Werktagen
  • Target Alle Allergin-1 (MILR1) Antikörper anzeigen
    Allergin-1 (MILR1) (Mast Cell Immunoglobulin-Like Receptor 1 (MILR1))
    Bindungsspezifität
    • 14
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 61-160
    Reaktivität
    • 25
    • 1
    Human
    Wirt
    • 22
    • 2
    • 1
    Kaninchen
    Klonalität
    • 23
    • 2
    Polyklonal
    Konjugat
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Allergin-1 Antikörper ist konjugiert mit Alexa Fluor 350
    Applikation
    • 12
    • 12
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Allergin-1
    Isotyp
    IgG
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C/-80 °C
    Informationen zur Lagerung
    Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles
    Haltbarkeit
    12 months
  • Target
    Allergin-1 (MILR1) (Mast Cell Immunoglobulin-Like Receptor 1 (MILR1))
    Andere Bezeichnung
    Allergin-1 (MILR1 Produkte)
    Synonyme
    Allergin-1, Gm885, Mca32, C17orf60, MCA-32, MCA32, mast cell immunoglobulin like receptor 1, mast cell immunoglobulin-like receptor 1, Milr1, MILR1
    Hintergrund

    As a major event in type allergic reaction,degranulation of mast cells is triggered by the interaction between specific IgEs and high affinity IgE receptors (FcRIs) on mast cell membrane,and is followed by the release of a battery of inflammatory mediators,such as histamine,leukotrienes and arachidonic acid,and these inflammatory mediators in turn induce a series of allergic symptoms.Recently,Allergin-1 has been found to be an immunoglobulin-like receptor preferentially expressed on mast cells.The crosslinking of Allergin-1 to FcRIs on mast cells may inhibit the signal transduction from FcRIs to intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM),generate ITIM inhibitory signals,which then participate in the regulation of mast cell degranulation,and finally block the initiation of allergic inflammation.

    Subcellular location: Cell membrane

    Synonyms: C17orf60,Chromosome 17 open reading frame 60.

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