BCAN Antikörper (AA 219-655)

Produktnummer ABIN1686637

Dieses Maus Monoklonal-Antikörper erkennt spezifisch BCAN in WB, ICC und IF. Er zeigt eine Reaktivität gegenüber Ratte.

Kurzübersicht für BCAN Antikörper (AA 219-655) (ABIN1686637)

Target: BCAN (Brevican (BCAN))

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BCAN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Klon: S294A-6

Produktdetails anti-BCAN Antikörper

Bindungsspezifität: AA 219-655

Spezifität: Detects ~140 kDa (and smaller due to proteolytic cleavage).

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Protein G Purified

Immunogen: Fusion protein amino acids 219-655 of rat Brevican

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise:

• WB (1:1000)
• optimal dilutions for assays should be determined by the user.

Kommentare:

1 μg/ml of ABIN1686637 was sufficient for detection of Brevican in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C

Details zu BCAN

Target: BCAN (Brevican (BCAN))

Andere Bezeichnung: Brevican

Hintergrund: Brevican is the most abundant chondroitin sulfate proteoglycan in the extracellular matrix of the adult brain. It is a member of the lectican family of aggregating extracellular matrix proteoglycans that bear chondroitin sulfate (CS) chains. It is highly expressed in the central nervous system and is thought to stabilize synapses and inhibit neural plasticity. Brevican is secreted from astrocytes and neurons as a 145 kD core protein that bears up to three, covalently-linked, CS chains. It is also is secreted as a 145 kD core protein without CS chains. When cleaved by extracellular glutamyl endopeptidases, the ADAMTSs, a 55 kD N-terminal fragment is formed that contains the unique C terminal epitope EAMESE.

Gen-ID: 25393

NCBI Accession: NP_001028837

UniProt: P55068

Pathways: Glycosaminoglycan Metabolic Process