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SYT7 Antikörper (AA 150-239)

SYT7 Reaktivität: Maus ICC, IF, IHC, WB Wirt: Maus Monoclonal S275-14 unconjugated
Produktnummer ABIN1686633
$474.50
Zzgl. Versandkosten $45.00
100 μg
Lieferung in 3 bis 4 Werktagen
  • Target Alle SYT7 Antikörper anzeigen
    SYT7 (Synaptotagmin VII (SYT7))
    Bindungsspezifität
    • 12
    • 9
    • 9
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 150-239
    Reaktivität
    • 33
    • 29
    • 8
    • 5
    • 5
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Maus
    Wirt
    • 30
    • 17
    • 1
    Maus
    Klonalität
    • 31
    • 17
    Monoklonal
    Konjugat
    • 19
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SYT7 Antikörper ist unkonjugiert
    Applikation
    • 40
    • 20
    • 15
    • 11
    • 10
    • 1
    • 1
    Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
    Spezifität
    Detects ~45 kDa. Does not cross-react with Synaptotagmin-6 (or others). Can identify other isoforms bands at ~65kD.
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Protein G Purified
    Immunogen
    Fusion protein amino acids 150-239 (Cytoplasmic C2A domain) of mouse Synaptotagmin-7
    Klon
    S275-14
    Isotyp
    IgG2b
  • Applikationshinweise
    • WB (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    1 μg/ml of ABIN1686633 was sufficient for detection of Synaptotagmin-7 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    -20°C
  • Target
    SYT7 (Synaptotagmin VII (SYT7))
    Andere Bezeichnung
    Synaptotagmin 7 (SYT7 Produkte)
    Synonyme
    CG10322, CG2381, Dmel\\CG2381, SYT7, Syt 7, Syt VII, dsyt7, syt7, MGC145945, IPCA-7, IPCA7, PCANAP7, SYT-VII, SYTVII, AI851541, B230112P13Rik, Synaptotagmin 7, synaptotagmin VII, synaptotagmin 7, Syt7, SYT7, syt7
    Hintergrund
    Synaptotagmins constitute a family of membrane-trafficking proteins that are characterized by an N-terminal transmembrane region (TMR), a variable linker, and two C-terminal C2 domains - C2A and C2B. There are 15 members in the mammalian synaptotagmin family. There are several C2-domain containing protein families that are related to synaptotagmins, including transmembrane (Ferlins, E-Syts, and MCTPs) and soluble (RIMs, Munc13s, synaptotagmin-related proteins and B/K) proteins. The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin participates in triggering neurotransmitter release at the synapse. The first domain mediates Ca(2+)-dependent phospholipid binding. The second C2 domain mediates interaction with Stonin 2. Synaptotagmin may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacylbackbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner, these are neurexins, syntaxin and AP2.
    Gen-ID
    54525
    NCBI Accession
    NP_061271
    UniProt
    Q9R0N7
    Pathways
    Synaptic Vesicle Exocytosis
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