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LARP1 Antikörper

LARP1 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN1680662
  • Target Alle LARP1 Antikörper anzeigen
    LARP1 (La Ribonucleoprotein Domain Family, Member 1 (LARP1))
    Reaktivität
    • 17
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 15
    • 2
    Kaninchen
    Klonalität
    • 17
    Polyklonal
    Konjugat
    • 17
    Dieser LARP1 Antikörper ist unkonjugiert
    Applikation
    • 16
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Kreuzreaktivität
    Human
    Produktmerkmale
    Polyclonal Antibodies
    Immunogen
    Recombinant Protein of human LARP1
    Isotyp
    IgG
    Top Product
    Discover our top product LARP1 Primärantikörper
  • Applikationshinweise
    WB,1:500 - 1:2000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    LARP1 (La Ribonucleoprotein Domain Family, Member 1 (LARP1))
    Andere Bezeichnung
    LARP1 (LARP1 Produkte)
    Synonyme
    RGD1306683 antikoerper, wu:fb92d03 antikoerper, wu:fd15e07 antikoerper, 3110040D16RIK antikoerper, MGC98945 antikoerper, LARP antikoerper, 1810024J12Rik antikoerper, 3110040D16Rik antikoerper, Larp antikoerper, mKIAA0731 antikoerper, La ribonucleoprotein domain family, member 1 antikoerper, La ribonucleoprotein domain family member 1 antikoerper, La ribonucleoprotein domain family member 1 L homeolog antikoerper, Larp1 antikoerper, larp1 antikoerper, LARP1 antikoerper, larp1.L antikoerper
    Hintergrund
    RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability. Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery. The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1. When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR of mRNA. Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif. Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes. Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR of mRNAs encoding ribosomal proteins and increases protein synthesis. Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation. Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis.,LARP1,LARP,Epigenetics & Nuclear Signaling,RNA Binding,LARP1
    Molekulargewicht
    116 kDa/123 kDa
    Gen-ID
    23367
    UniProt
    Q6PKG0
    Pathways
    SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion
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