IFIT3 Antikörper (AA 128-331)

Produktnummer ABIN1680389

Der Kaninchen Polyklonal Anti-IFIT3-Antikörper wurde für WB und IHC validiert. Er ist geeignet, IFIT3 in Proben von Maus zu detektieren.

Kurzübersicht für IFIT3 Antikörper (AA 128-331) (ABIN1680389)

Target: IFIT3 (Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IFIT3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-IFIT3 Antikörper

Bindungsspezifität: AA 128-331

Sequenz: ANPYSMECPE LECEEGWTRL KCGRNERAKM CFEKALEEKP KDPECSSGMA IAMFRLEEKP EKQFSVDALK QAMELNPQNQ YLKVLLALKL LRMGEEAEGE RLIKDALGKA PNQTDVLQKA AQFYKKKGNL DRAIELLGKA LRSTVNNSPL YSLVMCRYRE ILEQLQNKGD ADSSERRQRM AELRRLTMEF MQKTLQRRRS PLNS

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 128-331 of mouse IFIT3 (NP_034631.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:1000,IHC,1:100 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu IFIT3

Target: IFIT3 (Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3))

Andere Bezeichnung: IFIT3

Hintergrund: IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.,IFIT3,CIG-49,GARG-49,IFI60,IFIT4,IRG2,ISG60,P60,RIG-G,cig41,Immunology & Inflammation,Cytokines,Interferons,Cell Intrinsic Innate Immunity Signaling Pathway,IFIT3

Molekulargewicht: 47 kDa

Gen-ID: 15959

UniProt: O14879