DCLK1 Antikörper

Produktnummer ABIN1678754

Der Kaninchen Monoklonal Anti-DCLK1-Antikörper wurde für WB validiert. Er ist geeignet, DCLK1 in Proben von Human zu detektieren.

Kurzübersicht für DCLK1 Antikörper (ABIN1678754)

Target: DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser DCLK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-DCLK1 Antikörper

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Monoclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthesized peptide derived from human DCAMKL1/DCLK1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu DCLK1

Target: DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))

Andere Bezeichnung: DCLK1

Hintergrund: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010],CL1, CLICK1, DCAMKL1, DCDC3A, DCLK,Kinase,Neuroscience,Signal Transduction,DCLK1

Molekulargewicht: 82 kDa

Gen-ID: 9201

UniProt: O15075