MESP1 Antikörper

Produktnummer ABIN1589957

Dieses Anti-MESP1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MESP1 in WB und IHC. Geeignet für Human.

Kurzübersicht für MESP1 Antikörper (ABIN1589957)

Target: MESP1 (Mesoderm Posterior 1 (MESP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MESP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-MESP1 Antikörper

Verwendungszweck: MesP1 antibody

Spezifität: Recombinant human MesP1

Produktmerkmale: Chromosomal location: 15q26.1

Aufreinigung: Protein A purified

Immunogen: Recombinant human MesP1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: Use 1-5 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS

Handhabung: Centrifuge vial prior to opening.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.

Haltbarkeit: 24 months

Details zu MESP1

Target: MESP1 (Mesoderm Posterior 1 (MESP1))

Andere Bezeichnung: MesP1

Hintergrund: MESP1, bHLHc5,ES-cell-based cardiovascular repair requires an in-depth understanding of the molecular mechanisms underlying the differentiation of cardiovascular ES cells. A candidate cardiovascular-fate inducer is the bHLH transcription factor MesP1. As one of the earliest markers, it is expressed specifically in almost all cardiovascular precursors and is required for cardiac morphogenesis. It was shown that MesP1 is a key factor sufficient to induce the formation of ectopic heart tissue in vertebrates and increase cardiovasculogenesis by ES cells. Electrophysiological analysis showed all subtypes of cardiac ES-cell differentiation. MesP1 overexpression and knockdown experiments revealed a prominent function of MesP1 in a gene regulatory cascade, causing Dkk-1-mediated blockade of canonical Wnt-signalling. Independent evidence from ChIP and in vitro DNA-binding studies, expression analysis in wild-type and MesP knockout mice, and reporter assays confirm that Dkk-1 is a direct target of MesP1.

Gen-ID: 55897

NCBI Accession: NM_018670, NP_061140

UniProt: Q9BRJ9

Pathways: Regulation of Muscle Cell Differentiation