CCBE1 Antikörper (AA 159-251)

Produktnummer ABIN1589917

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch CCBE1 in WB und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für CCBE1 Antikörper (AA 159-251) (ABIN1589917)

Target: CCBE1 (Collagen and Calcium Binding EGF Domains 1 (CCBE1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CCBE1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-CCBE1 Antikörper

Bindungsspezifität: AA 159-251

Verwendungszweck: ccbe1 antibody

Spezifität: Recombinant human ccbe1 (Tyr35-Pro406) derived from Sf9 insect cells

Produktmerkmale: Chromosomal location: 18q21.32

Aufreinigung: Protein A purified

Immunogen: Highly pure (>98%) recombinant human ccbe1 (Cys159-Leu251) derived from E. coli.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: Use 2-5 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS

Handhabung: Centrifuge vial prior to opening. Avoid repeated freeze-thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.

Haltbarkeit: 24 months

Details zu CCBE1

Target: CCBE1 (Collagen and Calcium Binding EGF Domains 1 (CCBE1))

Andere Bezeichnung: ccbe1

Hintergrund: Collagen and calcium binding EGF domains 1, KIAA1983,The lymphatic system comprises a vascular system separate from the cardiovascular system, essential for immune responses, fluid homeostasis and fat absorption. Lymphatic vessels develop in a complex process termed lymphangiogenesis that involves budding, migration and proliferation of lymphatic endothelial progenitor cells. A few genes, such as FLT4, FOXC2 and SOX18, are known to be critically involved in lymph vessel formation in humans. Lymphedema, lymphangiectasias, mental retardation and unusual facial characteristics define the autosomal recessive Hennekam syndrome. Homozygosity mapping identified a critical chromosomal region containing ccbe1, encoding Collagen and Calcium-Binding EGF-domain-1, a secreted protein which is required for embryonic lymphangiogenesis in zebrafish. ccbe1 is not expressed in endothelial cells of lymph vessels, and it may be a component of the extracellular matrix. In zebrafish, ccbe1 expression was observed along the earliest migration routes of endothelial cells that sprout from the posterior cardinal vein and migrate circuitously before developing into lymphatic vessels. ccbe1 might therefore be involved in guidance of these migrating cells.

Gen-ID: 147372

NCBI Accession: NM_133459, NP_597716

UniProt: Q6UXH8