PROX1 Antikörper

Produktnummer ABIN1589859

Zitiert in 9+ Publikationen. Der Kaninchen Polyklonal anti-PROX1 Antikörper (ABIN1589859) detektiert spezifisch PROX1 in WB und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für PROX1 Antikörper (ABIN1589859)

Target: PROX1 (Prospero Homeobox 1 (PROX1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PROX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-PROX1 Antikörper

Verwendungszweck: Rabbit Anti-Human Prox-1 Polyclonal Antibody

Spezifität: Recombinant human Prox-1

Produktmerkmale: Chromosomal location: 1q32.2-q32.3

Aufreinigung: Protein A purified

Immunogen: Recombinant human Prox-1 (ABIN1589681)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: Use 1-5 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: 0.5X PBS, pH 7.2

Handhabung: Centrifuge vial prior to opening. Avoid repeated freeze-thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.

Haltbarkeit: 24 months

Referenzen für anti-PROX1 Antikörper (ABIN1589859)

Lee, Koh: "Coordinated lymphangiogenesis is critical in lymph node development and maturation." in: Developmental dynamics : an official publication of the American Association of Anatomists, (2016) (PubMed).

Quagliata, Klusmeier, Cremers, Pytowski, Harvey, Pettis, Thiele, Sleeman: "Inhibition of VEGFR-3 activation in tumor-draining lymph nodes suppresses the outgrowth of lymph node metastases in the MT-450 syngeneic rat breast cancer model." in: Clinical & experimental metastasis, Vol. 31, Issue 3, pp. 351-65, (2014) (PubMed).

Kaltezioti, Antoniou, Stergiopoulos, Rozani, Rohrer, Politis: "Prox1 regulates Olig2 expression to modulate binary fate decisions in spinal cord neurons." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 47, pp. 15816-31, (2014) (PubMed).

Sleeckx, Van Brantegem, Van den Eynden, Fransen, Casteleyn, Van Cruchten, Veldhuis Kroeze, Van Ginneken: "Angiogenesis in canine mammary tumours: a morphometric and prognostic study." in: Journal of comparative pathology, Vol. 150, Issue 2-3, pp. 175-83, (2014) (PubMed).

Trindade, Torrelo, Kutzner, Requena, Tellechea, Colmenero: "An immunohistochemical study of angiokeratomas of children." in: The American Journal of dermatopathology, Vol. 36, Issue 10, pp. 796-9, (2014) (PubMed).

Benevenuto de Andrade, Ramírez-Amador, Anaya-Saavedra, Martínez-Mata, Fonseca, Graner, Paes de Almeida: "Expression of PROX-1 in oral Kaposi's sarcoma spindle cells." in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, Vol. 43, Issue 2, pp. 132-6, (2014) (PubMed).

Dartsch, Schulte, Hägerling, Kiefer, Vestweber: "Fusing VE-cadherin to ?-catenin impairs fetal liver hematopoiesis and lymph but not blood vessel formation." in: Molecular and cellular biology, Vol. 34, Issue 9, pp. 1634-48, (2014) (PubMed).

Burger, Stuurman, Kok, Konijn, Schooneman, Niederreither, Coles, Agace, Christoffels, Mebius, van de Pavert, Bekker: "Involvement of neurons and retinoic acid in lymphatic development: new insights in increased nuchal translucency." in: Prenatal diagnosis, Vol. 34, Issue 13, pp. 1312-9, (2014) (PubMed).

Buttler, Badar, Seiffart, Laggies, Gross, Wilting, Weich: "De novo hem- and lymphangiogenesis by endothelial progenitor and mesenchymal stem cells in immunocompetent mice." in: Cellular and molecular life sciences : CMLS, Vol. 71, Issue 8, pp. 1513-27, (2014) (PubMed).

Details zu PROX1

Target: PROX1 (Prospero Homeobox 1 (PROX1))

Andere Bezeichnung: Prox-1

Hintergrund:

Synonyms: PROX1, W117m

Description: Prox-1 is a homeobox gene and acts as a master switch for lymphatic endothelial phenotype. Expression of Prox-1 in blood endothelial cells induces expression of other lymphatic marker genes. Together with Podoplanin, Prox-1 can be used to reliably distinguish lymphatic vessels from blood vessels. Prox-1 is expressed in CNS, eye, pancreas, liver and heart, and it is one of the most specific and reliable markers for lymphatic endothelial cells. Produced from sera of rabbits immunized with the recombinant highly conserved C-terminal part of the homeobox transcription factor Prox-1.

Gen-ID: 5629

NCBI Accession: NM_002763, NP_002754

UniProt: Q92786

Pathways: Stem Cell Maintenance, Regulation of Muscle Cell Differentiation