ESM1 Antikörper

Produktnummer ABIN1589852

Produktdetails anti-ESM1 Antikörper

Target: ESM1 (Endothelial Cell-Specific Molecule 1 (ESM1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ESM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Spezifität: Recombinant human ESM-1

Produktmerkmale: Chromosomal location: 5q11.2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: use 1-5 µg/mL

Kommentare:

Rabbit IG Polyclonal Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: 0.5X PBS, pH 7.2

Handhabung: Centrifuge vial prior to opening. Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: The lyophilized antibody is stable at room temperature for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 °C. Frozen aliquots are stable for at least 6 months when stored at -20 °C.

Haltbarkeit: 6 months

Details zu ESM1

Target: ESM1 (Endothelial Cell-Specific Molecule 1 (ESM1))

Andere Bezeichnung: Endocan/ESM-1 (ESM1 Produkte)

Synonyme: ESM1 antikoerper, zgc:153027 antikoerper, 0610042H23Rik antikoerper, AV004503 antikoerper, ESM-1 antikoerper, Pg25 antikoerper, endocan antikoerper, endothelial cell specific molecule 1 antikoerper, endothelial cell-specific molecule 1 antikoerper, ESM1 antikoerper, esm1 antikoerper, Esm1 antikoerper

Hintergrund: Endocan, also known as endothelial cell specific molecule1 (ESM1), is a secreted cysteine-rich dermatan sulfate (DS) proteoglycan primarily expressed by endothelial cells within the vascular capillary network in kidney and in the alveolar walls of the lung. Endocan expression has also been detected in different epithelia and in adipocytes. The expression of endocan is upregulated by TNFα, IL1β, or lipopolysaccharide and downregulated by IFNγ. The human Endocan gene encodes a 184 amino acid (aa) residues precursor protein with a 19 aa hydrophobic signal peptide and a 165 aa mature region with 18 Cysteine residues. The DS chain is covalently attached to serine 137. Endocan has been shown to bind CD11a/CD18 integrin (also known as lymphocyte functionassociated antigen1, LFA1) on human lymphocytes, monocytes and Jurkat cells, inhibiting its binding to ICAM-1 and reducing LFA1-mediated leukocyte activation. Endocan binds via its DS chain to hepatocyte growth factor (HGF) to enhance HGF mitogenic activity. Genetically engineered cells overexpressing endocan has been shown to induce tumor formation, suggesting that Endocan may be involved in the pathophysiology of tumor growth in vivo. Circulating Endocan can be detected in the serum from healthy subjects. In patients with lung cancer or acute and severe sepsis, elevated Endocan concentrations have been reported.
Synonyms: Endocan, ESM1

NCBI Accession: NP_008967, NM_007036

UniProt: Q9NQ30

Pathways: Growth Factor Binding