GLG1 Antikörper

Produktnummer ABIN1589833

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch GLG1 in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für GLG1 Antikörper (ABIN1589833)

Target: GLG1 (Golgi Glycoprotein 1 (GLG1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GLG1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GLG1 Antikörper

Verwendungszweck: ESL-1 antibody

Spezifität: Recombinant human soluble ESL-1

Aufreinigung: Protein A purified

Immunogen: Recombinant human soluble ESL-1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: Use 1-5 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS

Handhabung: Centrifuge vial prior to opening.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.

Haltbarkeit: 24 months

Details zu GLG1

Target: GLG1 (Golgi Glycoprotein 1 (GLG1))

Andere Bezeichnung: ESL-1

Hintergrund: Golgi apparatus protein-1, E-selectin ligand-1, Cysteine-rich fibroblast growth factor receptor,E-Selectin ligand-1/ESL-1 (GLG1, Golgi complex-Localized Glycoprotein 1, CFR1, MG160 and Cysteine-rich FGF receptor) is a 150-160 kDa glycoprotein. The amino acid sequence of MG160, a membrane sialoglycoprotein of the medial cisternae of the rat Golgi apparatus, is more than 90 % identical with CFR, a fibroblast growth factor (FGF) binding protein of chicken membranes, and with ESL-1, a ligand for E-selectin of plasma membranes of myeloid cells, furthermore, MG160, isolated by immunoaffinity chromatography from rat brain membranes, binds to basic FGF. The protein has a large luminal domain composed of an initial Proline-Glutamine-rich segment, encoded by an uninterrupted exonic sequence of several CAG-CAA repeats. Expansion of CAG repeats has been implicated in the etiology of several neurodegenerative diseases. The Proline-Glutamine-rich segment is followed by 16 cysteine-rich repeats that contain five potential Asparagine-linked glycosylation sites, which are conserved in the human, rat, mouse, and chicken. The large extracellular domain of the protein is followed by a single transmembrane domain and a 13-amino-acid cytoplasmic carboxy-terminal tail, which is identical to that in the chicken, rat, and mouse. It is expressed in both Golgi and/or the cell membrane of multiple cell typs, including liver stellate cells, neurons, cardiac myocytes, monocytes and bronchial epithelial cells. In the blood, GLG1/ESL-1 collaborates with PSGL-1 to mediate leukocyte binding to endothelial cell surfaces

Gen-ID: 2734

NCBI Accession: NM_001145666, NP_001139138

UniProt: Q92896