Peripherin Antikörper

Produktnummer ABIN1580457

Produktdetails anti-Peripherin Antikörper

Target: Peripherin (PRPH)

Reaktivität: Ratte, Säugetier

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Peripherin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Aufreinigung: conc. tissue culture supernatant

Klon: 8G2

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: We recommend trying the antibody at 1:500 for immunofluoresence and 1:5,000 of western blotting purposes.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4°C. For safest long-term storage, maintain aliquots at -80°C or at -20°C.

Details zu Peripherin

Target: Peripherin (PRPH)

Andere Bezeichnung: Peripherin (PRPH Produkte)

Synonyme: NEF4 antikoerper, PRPH1 antikoerper, Prph1 antikoerper, Perf antikoerper, nef4 antikoerper, prph1 antikoerper, MGC69454 antikoerper, if3 antikoerper, plasticin antikoerper, zgc:111926 antikoerper, peripherin antikoerper, peripherin L homeolog antikoerper, PRPH antikoerper, Prph antikoerper, prph antikoerper, prph.L antikoerper

Hintergrund: Peripherin is a approx. 57 kDa intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems, which gives the protein its name. Subsequently peripherin was found in some sensory and other neurons of the central nervous system and also in rat pheochromacytoma PC12 cells. Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas. Peripherin belongs to the Class III family of intermediate filament subunits which also includes vimentin, glial fibrillary acidic protein (GFAP) and desmin. Antibodies to peripherin can be used in identifying, classifying, and studying neurons throughout the nervous system. Peripherin is also a good diagnostic marker for ballooned axons seen in Lou Gehrig's disease (Amyotrophic lateral sclerosis) and some neuronally derived tumors. Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes. Peripherin is not related to peripherin/RDS, a protein of the photoreceptor outer membrane mutations of which are causative of certain forms of slow retinal degeneration. The characterization of this antibody has been published and has been on the market through many companies for several years, so many other publications make use of this reagent. The HGNC name for this protein is PRPH.