DBN1 Antikörper (AA 1-326) (PE)

Produktnummer ABIN1558085

Der Maus Monoklonal Anti-DBN1-Antikörper wurde für ICFC validiert. Er ist geeignet, DBN1 in Proben von Human zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für DBN1 Antikörper (AA 1-326) (PE) (ABIN1558085)

Target: DBN1 (Drebrin 1 (DBN1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser DBN1 Antikörper ist konjugiert mit PE

Applikation: Intracellular Flow Cytometry (ICFC)

Klon: DBN-N-03

Produktdetails anti-DBN1 Antikörper (PE)

Bindungsspezifität: AA 1-326

Verwendungszweck: Anti-Drebrin PE

Spezifität: The mouse monoclonal antibody DBN-N-03 recognizes drebrin, an approximately 100-125 kDa intracellular regulator of actin cytoskeleton.

Kreuzreaktivität (Details): Human

Aufreinigung: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: Bacterially expressed N-terminal fragment of recombinant human drebrin (aa 1-326)

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests. Intracellular staining.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: No reconstitution is necessary.

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze.
Avoid prolonged exposure to light.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Referenzen für anti-DBN1 Antikörper (PE) (ABIN1558085)

Vaskova, Kovac, Volna, Angelisova, Mejstrikova, Zuna, Brdicka, Hrusak: "High expression of cytoskeletal protein drebrin in TEL/AML1pos B-cell precursor acute lymphoblastic leukemia identified by a novel monoclonal antibody." in: Leukemia research, Vol. 35, Issue 8, pp. 1111-3, (2011) (PubMed).

Details zu DBN1

Target: DBN1 (Drebrin 1 (DBN1))

Andere Bezeichnung: Drebrin

Hintergrund: Drebrin 1,Drebrin is an actin-binding protein, which is expressed mainly in neurons and plays important role in their morphogenesis. The highest level of its expression is in developing brain. Both in neurons and non-neuronal cells drebrin acts as a key regulator of actin cytoskeleton remodelling, affecting especially intercellular junctions, such as dendritic spines of neurons or the immune synapses of T cells. Decrease of drebrin amount in the brain seems to be associated with Alzheimer's disease and Down syndrome, and in case of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) lower drebrin expression correlates with higher risk of relapse.,DBN, D0S117E

Gen-ID: 1627

UniProt: Q16643

Pathways: Maintenance of Protein Location