Estrogen Receptor alpha Antikörper (AA 246-273)

Produktnummer ABIN1539856

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Estrogen Receptor alpha in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Estrogen Receptor alpha Antikörper (AA 246-273) (ABIN1539856)

Target: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Estrogen Receptor alpha Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 415CT16-3-2-1

Produktdetails anti-Estrogen Receptor alpha Antikörper

Bindungsspezifität: AA 246-273

Homologie: B, Hs, M, Pig, Rat

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This ESR1/ER antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 246-273 amino acids from human ESR1/ER.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1:100~250

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: ESR1/ER Antibody can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Haltbarkeit: 6 months

Details zu Estrogen Receptor alpha

Target: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Andere Bezeichnung: ESR1/ER

Hintergrund: This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.

Molekulargewicht: 66216

Gen-ID: 2099

NCBI Accession: NP_000116, NP_001116212, NP_001116213, NP_001116214

UniProt: P03372

Pathways: Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly