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ATXN7 Antikörper (AA 354-381)

Der Rabbit Polyclonal Anti-ATXN7-Antikörper wurde für WB validiert. Er ist geeignet, ATXN7 in Proben von Human zu detektieren.
Produktnummer ABIN1538351

Kurzübersicht für ATXN7 Antikörper (AA 354-381) (ABIN1538351)

Target

Alle ATXN7 Antikörper anzeigen
ATXN7 (Ataxin 7 (ATXN7))

Reaktivität

  • 31
  • 29
  • 20
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
Human

Wirt

  • 46
  • 1
Kaninchen

Klonalität

  • 46
  • 1
Polyklonal

Konjugat

  • 17
  • 4
  • 4
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser ATXN7 Antikörper ist unkonjugiert

Applikation

  • 35
  • 20
  • 13
  • 13
  • 5
  • 3
  • 3
  • 3
  • 2
  • 1
Western Blotting (WB)

Klon

RB36286
  • Bindungsspezifität

    • 15
    • 7
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 354-381

    Homologie

    M

    Aufreinigung

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    Immunogen

    This ATXN7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 354-381 amino acids from the Central region of human ATXN7.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    WB: 1:1000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    ATXN7 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

    Haltbarkeit

    6 months
  • Target

    ATXN7 (Ataxin 7 (ATXN7))

    Andere Bezeichnung

    ATXN7

    Hintergrund

    The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the 'pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. This locus has been mapped to chromosome 3, and it has been determined that the diseased allele associated with spinocerebellar ataxia-7 contains 38-130 CAG repeats (near the N-terminus), compared to 7-17 in the normal allele. The encoded protein is a component of the SPT3/TAF9/GCN5 acetyltransferase (STAGA) and TBP-free TAF-containing (TFTC) chromatin remodeling complexes, and it thus plays a role in transcriptional regulation. Alternative splicing results in multiple transcript variants.

    Molekulargewicht

    95451

    Gen-ID

    6314

    NCBI Accession

    NP_000324, NP_001121621, NP_001170858

    UniProt

    O15265
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