Shugoshin Antikörper (AA 339-367)

Produktnummer ABIN1538328

Dieses Anti-Shugoshin-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Shugoshin in WB. Geeignet für Human.

Kurzübersicht für Shugoshin Antikörper (AA 339-367) (ABIN1538328)

Target: Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Shugoshin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB36785

Produktdetails anti-Shugoshin Antikörper

Bindungsspezifität: AA 339-367

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SGOL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 339-367 amino acids from the Central region of human SGOL1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: SGOL1 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Haltbarkeit: 6 months

Details zu Shugoshin

Target: Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))

Andere Bezeichnung: SGOL1

Hintergrund: SGOL1 plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity.

Molekulargewicht: 64190

Gen-ID: 151648

NCBI Accession: NP_001012409, NP_001012410, NP_001012411, NP_001012412, NP_001012413, NP_001186180, NP_001186181, NP_001186182, NP_001186183, NP_001186184, NP_001186185, NP_001186186, NP_612493

UniProt: Q5FBB7

Pathways: Maintenance of Protein Location