TFE3 Antikörper (C-Term)

Produktnummer ABIN1537398

Dieses Anti-TFE3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TFE3 in WB. Geeignet für Human und Maus.

Kurzübersicht für TFE3 Antikörper (C-Term) (ABIN1537398)

Target: TFE3 (Transcription Factor E3 (TFE3))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TFE3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB20264

Produktdetails anti-TFE3 Antikörper

Bindungsspezifität: AA 489-516, C-Term

Homologie: B

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TFE3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 489-516 amino acids from the C-terminal region of human TFE3.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: TFE3 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Haltbarkeit: 6 months

Details zu TFE3

Target: TFE3 (Transcription Factor E3 (TFE3))

Andere Bezeichnung: TFE3

Hintergrund: The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB and TFEC. The TEF3 protein encoded by this gene activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer. The TFEC protein forms heterodimers with the TEF3 protein and inhibits TFE3-dependent transcription activation. The TEF3 protein interacts with transcription regulators such as E2F3, SMAD3, and LEF-1, and is involved in TGF-beta-induced transcription, playing important roles in cell growth, proliferation, and osteoclast and macrophage differentiation. The TFE3 protein also activates hepatic IRS-2 gene, and induces hexokinase II (HK2) and insulin-induced gene 1 (INSIG1), it participates in insulin signaling and could be a therapeutic target for diabetes. This gene is also involved in chromosomal translocations, resulting in different fusion gene products in papillary renal cell carcinomas and alveolar soft part sarcomas, such as PRCC-TFE3, RCC17-TFE3, PSF-TFE3, NonO (p54nrb)-TFE3 and ASPL-TFE3.

Molekulargewicht: 61521

Gen-ID: 7030

NCBI Accession: NP_006512

UniProt: P19532