BGLF4 (AA 386-417), (C-Term) Antikörper

Produktnummer ABIN1537299

Zitiert in 3+ Publikationen. Der Kaninchen Polyklonal anti-BGLF4 Antikörper (Klon RB3734) (ABIN1537299) detektiert spezifisch BGLF4 in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für BGLF4 (AA 386-417), (C-Term) Antikörper (ABIN1537299)

Target: BGLF4

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB3734

Produktdetails

Bindungsspezifität: AA 386-417, C-Term

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This BGLF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 386-417 amino acids from the C-terminal region of human BGLF4.

Isotyp: Ig Fraction

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen

Sun, Bristol, Iwahori, Hagemeier, Meng, Barlow, Fingeroth, Tarakanova, Kalejta, Kenney: "Hsp90 inhibitor 17-DMAG decreases expression of conserved herpesvirus protein kinases and reduces virus production in Epstein-Barr virus-infected cells." in: Journal of virology, Vol. 87, Issue 18, pp. 10126-38, (2013) (PubMed).

Meng, Hagemeier, Fingeroth, Gershburg, Pagano, Kenney: "The Epstein-Barr virus (EBV)-encoded protein kinase, EBV-PK, but not the thymidine kinase (EBV-TK), is required for ganciclovir and acyclovir inhibition of lytic viral production." in: Journal of virology, Vol. 84, Issue 9, pp. 4534-42, (2010) (PubMed).

Meng, Hagemeier, Kuny, Kalejta, Kenney: "Simian virus 40 T/t antigens and lamin A/C small interfering RNA rescue the phenotype of an Epstein-Barr virus protein kinase (BGLF4) mutant." in: Journal of virology, Vol. 84, Issue 9, pp. 4524-33, (2010) (PubMed).

Antigendetails

Target: BGLF4

Hintergrund: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.

Molekulargewicht: 48351

Gen-ID: 3783704

UniProt: P13288