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Zona Pellucida Glycoprotein 3 Antikörper (C-Term)

ZP3 Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB36988 unconjugated
Produktnummer ABIN1537191
  • Target Alle Zona Pellucida Glycoprotein 3 (ZP3) Antikörper anzeigen
    Zona Pellucida Glycoprotein 3 (ZP3)
    Bindungsspezifität
    • 8
    • 7
    • 6
    • 2
    • 1
    • 1
    AA 353-380, C-Term
    Reaktivität
    • 22
    • 3
    • 3
    • 2
    • 2
    • 2
    Human
    Wirt
    • 20
    • 2
    Kaninchen
    Klonalität
    • 22
    Polyklonal
    Konjugat
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser Zona Pellucida Glycoprotein 3 Antikörper ist unkonjugiert
    Applikation
    • 20
    • 14
    • 3
    • 1
    Western Blotting (WB)
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This ZP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 353-380 amino acids from the C-terminal region of human ZP3.
    Klon
    RB36988
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product ZP3 Primärantikörper
  • Applikationshinweise
    WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    ZP3 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.
    Haltbarkeit
    6 months
  • Mask, Schoenecker, Kane, Ransom, Bruemmer: "Serum antibody immunoreactivity to equine zona protein after SpayVac vaccination." in: Theriogenology, Vol. 84, Issue 2, pp. 261-7, (2015) (PubMed).

  • Target
    Zona Pellucida Glycoprotein 3 (ZP3)
    Andere Bezeichnung
    ZP3 (ZP3 Produkte)
    Synonyme
    ZP3A antikoerper, ZP3B antikoerper, ZPC antikoerper, Zp-3 antikoerper, zp3.2 antikoerper, Zp-3B antikoerper, zona pellucida glycoprotein 3 antikoerper, zona pellucida sperm-binding protein 3 antikoerper, ZP3 antikoerper, zp3 antikoerper, Zp3 antikoerper
    Hintergrund
    The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus, however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene.
    Molekulargewicht
    47018
    Gen-ID
    7784
    NCBI Accession
    NP_001103824, NP_009086
    UniProt
    P21754
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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