Zona Pellucida Glycoprotein 3 Antikörper (C-Term)

Produktnummer ABIN1537191

Dieses Anti-Zona Pellucida Glycoprotein 3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Zona Pellucida Glycoprotein 3 in WB. Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für Zona Pellucida Glycoprotein 3 Antikörper (C-Term) (ABIN1537191)

Target: Zona Pellucida Glycoprotein 3 (ZP3)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Zona Pellucida Glycoprotein 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB36988

Produktdetails anti-Zona Pellucida Glycoprotein 3 Antikörper

Bindungsspezifität: AA 353-380, C-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ZP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 353-380 amino acids from the C-terminal region of human ZP3.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: ZP3 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Haltbarkeit: 6 months

Referenzen für anti-Zona Pellucida Glycoprotein 3 Antikörper (ABIN1537191)

Mask, Schoenecker, Kane, Ransom, Bruemmer: "Serum antibody immunoreactivity to equine zona protein after SpayVac vaccination." in: Theriogenology, Vol. 84, Issue 2, pp. 261-7, (2015) (PubMed).

Details zu Zona Pellucida Glycoprotein 3

Target: Zona Pellucida Glycoprotein 3 (ZP3)

Andere Bezeichnung: ZP3

Hintergrund: The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus, however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene.

Molekulargewicht: 47018

Gen-ID: 7784

NCBI Accession: NP_001103824, NP_009086

UniProt: P21754

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process