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ACER1 Antikörper (C-Term)

ACER1 Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB37377 unconjugated
Produktnummer ABIN1536908
  • Target Alle ACER1 Antikörper anzeigen
    ACER1 (Alkaline Ceramidase 1 (ACER1))
    Bindungsspezifität
    • 7
    • 7
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 236-263, C-Term
    Reaktivität
    • 29
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 29
    Kaninchen
    Klonalität
    • 29
    Polyklonal
    Konjugat
    • 12
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ACER1 Antikörper ist unkonjugiert
    Applikation
    • 20
    • 17
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This ACER1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-263 amino acids from the C-terminal region of human ACER1.
    Klon
    RB37377
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product ACER1 Primärantikörper
  • Applikationshinweise
    WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    ACER1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.
    Haltbarkeit
    6 months
  • Target
    ACER1 (Alkaline Ceramidase 1 (ACER1))
    Andere Bezeichnung
    ACER1 (ACER1 Produkte)
    Synonyme
    ASAH3 antikoerper, asah3 antikoerper, zgc:110285 antikoerper, ALKCDase1 antikoerper, 2310024P18Rik antikoerper, AI662009 antikoerper, Alkcdase1 antikoerper, Asah3 antikoerper, Cer1 antikoerper, alkaline ceramidase 1 antikoerper, ACER1 antikoerper, acer1 antikoerper, Acer1 antikoerper
    Hintergrund
    Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081], Sun et al., 2008 [PubMed 17713573]).
    Molekulargewicht
    31095
    Gen-ID
    125981
    NCBI Accession
    NP_597999
    UniProt
    Q8TDN7
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