ACER1 Antikörper (C-Term)

Produktnummer ABIN1536908

Der Kaninchen Polyklonal Anti-ACER1-Antikörper wurde für WB validiert. Er ist geeignet, ACER1 in Proben von Human zu detektieren.

Kurzübersicht für ACER1 Antikörper (C-Term) (ABIN1536908)

Target: ACER1 (Alkaline Ceramidase 1 (ACER1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ACER1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB37377

Produktdetails anti-ACER1 Antikörper

Bindungsspezifität: AA 236-263, C-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ACER1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-263 amino acids from the C-terminal region of human ACER1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: ACER1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Haltbarkeit: 6 months

Details zu ACER1

Target: ACER1 (Alkaline Ceramidase 1 (ACER1))

Andere Bezeichnung: ACER1

Hintergrund: Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081], Sun et al., 2008 [PubMed 17713573]).

Molekulargewicht: 31095

Gen-ID: 125981

NCBI Accession: NP_597999

UniProt: Q8TDN7