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USP8 Antikörper (C-Term)

This anti-USP8 antibody (ABIN1536612) is a Mouse Monoclonal antibody detecting USP8 in WB. Suitable for Human.
Produktnummer ABIN1536612

Kurzübersicht für USP8 Antikörper (C-Term) (ABIN1536612)

Target

Alle USP8 Antikörper anzeigen
USP8 (Ubiquitin Specific Peptidase 8 (USP8))

Reaktivität

  • 38
  • 4
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 35
  • 2
  • 1
Maus

Klonalität

  • 36
  • 2
Monoklonal

Konjugat

  • 28
  • 2
  • 2
  • 2
  • 2
  • 2
Dieser USP8 Antikörper ist unkonjugiert

Applikation

  • 35
  • 16
  • 15
  • 8
  • 7
  • 5
  • 4
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB)

Klon

460CT35-1-6
  • Bindungsspezifität

    • 7
    • 7
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-30, C-Term

    Homologie

    M

    Aufreinigung

    Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

    Immunogen

    This USP8 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the C-terminal region of human USP8.

    Isotyp

    IgG1
  • Applikationshinweise

    WB: 1:500~4000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Mouse monoclonal antibody supplied in crude ascites with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    USP8 Antibody (C-term C1072)(Ascites) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

    Haltbarkeit

    6 months
  • Target

    USP8 (Ubiquitin Specific Peptidase 8 (USP8))

    Andere Bezeichnung

    USP8

    Hintergrund

    Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules.

    Molekulargewicht

    127523

    Gen-ID

    9101

    NCBI Accession

    NP_001122082, NP_001122083, NP_005145

    UniProt

    P40818
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