Actin Antikörper

Produktnummer ABIN1536597

Produktdetails anti-Actin Antikörper

Target: Actin (ACTA1) (Actin, alpha 1, Skeletal Muscle (ACTA1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Actin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Homologie: B, C, M, Pig, Rb, Rat

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This ACTA1 monoclonal antibody is generated from mouse immunized with ACTA1 recombinant protein.

Klon: 337CT30-10-1

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:1000. WB: 1:1000. IHC-P: 1:10~50. IHC-P: 1:10~50. FC: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: ACTA1 Antibody can be refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-Actin Antikörper (ABIN1536597)

Vuković, Jevtić, Zhang, Stohr, Levy: "Nuclear size is sensitive to NTF2 protein levels in a manner dependent on Ran binding." in: Journal of cell science, Vol. 129, Issue 6, pp. 1115-27, (2017) (PubMed).

Edens, Dilsaver, Levy: "PKC-mediated phosphorylation of nuclear lamins at a single serine residue regulates interphase nuclear size in Xenopus and mammalian cells." in: Molecular biology of the cell, Vol. 28, Issue 10, pp. 1389-1399, (2017) (PubMed).

Details zu Actin

Target: Actin (ACTA1) (Actin, alpha 1, Skeletal Muscle (ACTA1))

Andere Bezeichnung: ACTA1 (ACTA1 Produkte)

Hintergrund: The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects.

Molekulargewicht: 42051

Gen-ID: 58

NCBI Accession: NP_001091

UniProt: P68133

Pathways: Caspase Kaskade in der Apoptose, Myometrial Relaxation and Contraction, Skeletal Muscle Fiber Development