TRHR Antikörper (AA 195-244)
Kurzübersicht für TRHR Antikörper (AA 195-244) (ABIN1536075)
Target
Alle TRHR Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 195-244
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Verwendungszweck
- TRH-R1 Antibody
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Spezifität
- TRH-R1 Polyclonal Antibody detects endogenous levels of TRH-R1 protein.
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Aufreinigung
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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Reinheit
- > 95 %
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Immunogen
- The antiserum was produced against synthesized peptide derived from human TRHR. AA range:195-244
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Isotyp
- IgG
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Applikationshinweise
- WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 mg/mL
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Buffer
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20°C/1 year
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Haltbarkeit
- 12 months
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: "The PI3K/Akt and ERK pathways elevate thyroid hormone receptor ?1 and TRH receptor to decrease thyroid hormones after exposure to PCB153 and p,p'-DDE." in: Chemosphere, Vol. 118, pp. 229-38, (2014) (PubMed).
: "JNK pathway decreases thyroid hormones via TRH receptor: a novel mechanism for disturbance of thyroid hormone homeostasis by PCB153." in: Toxicology, Vol. 302, Issue 1, pp. 68-76, (2012) (PubMed).
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- TRHR (Thyrotropin-Releasing Hormone Receptor (TRHR))
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Andere Bezeichnung
- TRHR
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Hintergrund
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Synonyms: TRHR, Thyrotropin-releasing hormone receptor, TRH-R, Thyroliberin receptor
Background: This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance. [provided by RefSeq, Sep 2011],
Gene Name: TRHR
Protein Name: Thyrotropin-releasing hormone receptor
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Molekulargewicht
- 45 kDa
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Gen-ID
- 7201
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OMIM
- 188545
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UniProt
- P34981
Target
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