BAI1 Antikörper (AA 691-740)

Produktnummer ABIN1535650

Der Kaninchen Polyklonal anti-BAI1 Antikörper wird verwendet zum Nachweis von BAI1 in Proben von Human und Maus. Er wurde validiert für IHC, WB, ELISA und IF.

Kurzübersicht für BAI1 Antikörper (AA 691-740) (ABIN1535650)

Target: BAI1 (Brain-Specific Angiogenesis Inhibitor 1 (BAI1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BAI1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-BAI1 Antikörper

Bindungsspezifität: AA 691-740

Verwendungszweck: BAI-1 Antibody

Spezifität: BAI-1 Polyclonal Antibody detects endogenous levels of BAI-1 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human BAI1. AA range:691-740

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu BAI1

Target: BAI1 (Brain-Specific Angiogenesis Inhibitor 1 (BAI1))

Andere Bezeichnung: BAI1

Hintergrund:

Synonyms: BAI1; Brain-specific angiogenesis inhibitor 1

Background: Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family,

Gene Name: BAI1

Protein Name: Brain-specific angiogenesis inhibitor 1

Molekulargewicht: 173 kDa

Gen-ID: 575

OMIM: 602682

UniProt: O14514

Pathways: p53 Signalweg