SESN1 Antikörper (AA 271-320)

Produktnummer ABIN1535359

Der Kaninchen Polyklonal anti-SESN1 Antikörper wird verwendet zum Nachweis von SESN1 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, ELISA, IHC und IF.

Kurzübersicht für SESN1 Antikörper (AA 271-320) (ABIN1535359)

Target: SESN1 (Sestrin 1 (SESN1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SESN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-SESN1 Antikörper

Bindungsspezifität: AA 271-320

Verwendungszweck: PA26 Antibody

Spezifität: PA26 Polyclonal Antibody detects endogenous levels of PA26 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human SESN1. AA range:271-320

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu SESN1

Target: SESN1 (Sestrin 1 (SESN1))

Andere Bezeichnung: SESN1

Hintergrund:

Synonyms: SESN1, PA26, SEST1, Sestrin-1, p53-regulated protein PA26

Background: This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010],

Gene Name: SESN1

Protein Name: Sestrin-1

Molekulargewicht: 56 kDa

Gen-ID: 27244

OMIM: 606103

UniProt: Q9Y6P5