Prosaposin Antikörper (AA 307-356)

Produktnummer ABIN1535203

Der Kaninchen Polyklonal anti-Prosaposin Antikörper wird verwendet zum Nachweis von Prosaposin in Proben von Human, Maus und Ratte. Er wurde validiert für WB, IHC, ELISA und IF.

Kurzübersicht für Prosaposin Antikörper (AA 307-356) (ABIN1535203)

Target: Prosaposin (PSAP)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Prosaposin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-Prosaposin Antikörper

Bindungsspezifität: AA 307-356

Verwendungszweck: Saposin Antibody

Spezifität: Saposin Polyclonal Antibody detects endogenous levels of Saposin protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human PSAP. AA range:307-356

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu Prosaposin

Target: Prosaposin (PSAP)

Andere Bezeichnung: PSAP

Hintergrund:

Synonyms: PSAP, GLBA, SAP1, Proactivator polypeptide

Background: This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016],

Gene Name: PSAP

Protein Name: Proactivator polypeptide

Molekulargewicht: 58 kDa

Gen-ID: 5660

OMIM: 176801

UniProt: P07602

Pathways: Positive Regulation of Endopeptidase Activity