MBTPS2 Antikörper (AA 301-350)

Produktnummer ABIN1535018

Der Kaninchen Polyklonal anti-MBTPS2 Antikörper (ABIN1535018) detektiert spezifisch MBTPS2 in ELISA, WB, IF und IP. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für MBTPS2 Antikörper (AA 301-350) (ABIN1535018)

Target: MBTPS2 (Membrane-Bound Transcription Factor Peptidase, Site 2 (MBTPS2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MBTPS2 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Produktdetails anti-MBTPS2 Antikörper

Bindungsspezifität: AA 301-350

Verwendungszweck: S2P Antibody

Spezifität: S2P Polyclonal Antibody detects endogenous levels of S2P protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human MBTPS2. AA range:301-350

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-2000 IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu MBTPS2

Target: MBTPS2 (Membrane-Bound Transcription Factor Peptidase, Site 2 (MBTPS2))

Andere Bezeichnung: MBTPS2

Hintergrund:

Synonyms: MBTPS2, S2P, Membrane-bound transcription factor site-2 protease, Endopeptidase S2P, Sterol regulatory element-binding proteins intramembrane protease, SREBPs intramembrane protease

Background: This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome), IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.[provided by RefSeq, Aug 2009],

Gene Name: MBTPS2

Protein Name: Membrane-bound transcription factor site-2 protease

Molekulargewicht: 57 kDa

Gen-ID: 51360

OMIM: 300294

UniProt: O43462

Pathways: ER-Nucleus Signaling