ZNRF2 Antikörper (AA 161-210)

Produktnummer ABIN1534873

Der Kaninchen Polyklonal anti-ZNRF2 Antikörper wird verwendet zum Nachweis von ZNRF2 in Proben von Human und Maus. Er wurde validiert für IF, IHC und ELISA.

Kurzübersicht für ZNRF2 Antikörper (AA 161-210) (ABIN1534873)

Target: ZNRF2 (Zinc and Ring Finger 2 (ZNRF2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZNRF2 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA

Produktdetails anti-ZNRF2 Antikörper

Bindungsspezifität: AA 161-210

Verwendungszweck: ZNRF2 Antibody

Spezifität: ZNRF2 Polyclonal Antibody detects endogenous levels of ZNRF2 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human ZNRF2. AA range:161-210

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu ZNRF2

Target: ZNRF2 (Zinc and Ring Finger 2 (ZNRF2))

Andere Bezeichnung: ZNRF2

Hintergrund:

Synonyms: ZNRF2, RNF202, E3 ubiquitin-protein ligase ZNRF2, Protein Ells2, RING finger protein 202, Zinc/RING finger protein 2

Background: domain:The RING-type zinc finger domain is required for E3 ligase activity.,function:May play a role in the establisment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.,pathway:Protein modification, protein ubiquitination.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Present in presynaptic plasma membranes in neurons.,subunit:Interacts with UBE2N.,tissue specificity:Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney.,

Gene Name: ZNRF2

Protein Name: E3 ubiquitin-protein ligase ZNRF2

Molekulargewicht: 24 kDa

Gen-ID: 223082

OMIM: 612061

UniProt: Q8NHG8

Pathways: Synaptic Membrane