CLDN8 Antikörper (AA 81-130)

Produktnummer ABIN1534783

Der Kaninchen Polyklonal anti-CLDN8 Antikörper wird verwendet zum Nachweis von CLDN8 in Proben von Human, Maus und Ratte. Er wurde validiert für WB und ELISA.

Kurzübersicht für CLDN8 Antikörper (AA 81-130) (ABIN1534783)

Target: CLDN8 (Claudin 8 (CLDN8))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CLDN8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-CLDN8 Antikörper

Bindungsspezifität: AA 81-130

Verwendungszweck: Claudin-8 Antibody

Spezifität: Claudin-8 Polyclonal Antibody detects endogenous levels of Claudin-8 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human CLDN8. AA range:81-130

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu CLDN8

Target: CLDN8 (Claudin 8 (CLDN8))

Andere Bezeichnung: CLDN8

Hintergrund:

Synonyms: CLDN8, Claudin-8

Background: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.[provided by RefSeq, May 2010],

Gene Name: CLDN8

Protein Name: Claudin-8

Molekulargewicht: 24 kDa

Gen-ID: 9073

OMIM: 611231

UniProt: P56748

Pathways: Hepatitis C