MED12 Antikörper (AA 611-660)

Produktnummer ABIN1534053

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch MED12 in ELISA, IHC, WB und IF. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für MED12 Antikörper (AA 611-660) (ABIN1534053)

Target: MED12 (Mediator Complex Subunit 12 (MED12))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MED12 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-MED12 Antikörper

Bindungsspezifität: AA 611-660

Verwendungszweck: TRAP230 Antibody

Spezifität: TRAP230 Polyclonal Antibody detects endogenous levels of TRAP230 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human MED12. AA range:611-660

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu MED12

Target: MED12 (Mediator Complex Subunit 12 (MED12))

Andere Bezeichnung: MED12

Hintergrund:

Synonyms: MED12, ARC240, CAGH45, HOPA, KIAA0192, TNRC11, TRAP230, Mediator of RNA polymerase II transcription subunit 12, Activator-recruited cofactor 240 kDa component, ARC240, CAG repeat protein 45, Mediator complex subunit 12, OPA-containing prote

Background: The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which containsThe protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009],

Gene Name: MED12

Protein Name: Mediator of RNA polymerase II transcription subunit 12

Molekulargewicht: 247 kDa

Gen-ID: 9968

OMIM: 300188

UniProt: Q93074

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Stem Cell Maintenance, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha, Tube Formation