TNS3 Antikörper (AA 541-590)

Produktnummer ABIN1533957

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch TNS3 in IHC, ELISA und IF. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für TNS3 Antikörper (AA 541-590) (ABIN1533957)

Target: TNS3 (Tensin 3 (TNS3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TNS3 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-TNS3 Antikörper

Bindungsspezifität: AA 541-590

Verwendungszweck: Tensin3 Antibody

Spezifität: Tensin3 Polyclonal Antibody detects endogenous levels of Tensin3 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human TENS3. AA range:541-590

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu TNS3

Target: TNS3 (Tensin 3 (TNS3))

Hintergrund:

Synonyms: TNS3, TEM6, TENS1, TPP, Tensin-3, Tensin-like SH2 domain-containing protein 1, Tumor endothelial marker 6

Background: function:May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development.,induction:EGF induces down-regulation.,PTM:Epidermal growth factor(EGF) induces tyrosine phosphorylation in a time- and dose-dependent manner.,similarity:Contains 1 C2 tensin-type domain.,similarity:Contains 1 phosphatase tensin-type domain.,similarity:Contains 1 SH2 domain.,subunit:EGF promotes the interaction with EGFR. Interacts with PTK2 and BCAR1. Tyrosine phosphorylation is critical for these interactions.,tissue specificity:Expressed in umbilical vein endothelial cells, epithelial cells, and fibroblasts cells (at protein level). Highly expressed in thyroid, kidney and placenta. Low expression in heart, skeletal muscle, spleen, liver, and lung. Expressed in tumor endothelial cells. Expression seems to be down-regulated in thyroid tumor tissues and in anaplastic carcinomas.,

Gene Name: TNS3

Protein Name: Tensin-3

Molekulargewicht: 155 kDa

Gen-ID: 64759

OMIM: 606825

UniProt: Q68CZ2