PSKH1 Antikörper (AA 261-310)

Produktnummer ABIN1533610

Der Kaninchen Polyklonal anti-PSKH1 Antikörper wird verwendet zum Nachweis von PSKH1 in Proben von Human und Maus. Er wurde validiert für WB, IHC, ELISA und IF.

Kurzübersicht für PSKH1 Antikörper (AA 261-310) (ABIN1533610)

Target: PSKH1 (Protein Serine Kinase H1 (PSKH1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PSKH1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-PSKH1 Antikörper

Bindungsspezifität: AA 261-310

Verwendungszweck: PSK-H1 Antibody

Spezifität: PSK-H1 Polyclonal Antibody detects endogenous levels of PSK-H1 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human KPSH1. AA range:261-310

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu PSKH1

Target: PSKH1 (Protein Serine Kinase H1 (PSKH1))

Hintergrund:

Synonyms: PSKH1, Serine/threonine-protein kinase H1, Protein serine kinase H1, PSK-H1

Background: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Activity depends on Ca(2+) concentration.,function:May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing.,PTM:Autophosphorylated on serine residues.,PTM:Myristoylated. Required for membrane association. Prerequisite for palmitoylation to occur.,PTM:Palmitoylated.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subcellular location:Localized in the Brefeldin A-sensitive Golgi compartment, at centrosomes, in the nucleus with a somewhat speckle-like presence, membrane-associated to the endoplasmic reticulum (ER) and the plasma membrane (PM), and more diffusely in the cytoplasm. Found to concentrate in splicing factor compartments (SFCs) within the nucleus of interphase cells. The acylation-negative form may be only cytoplasmic and nuclear. Acylation seems to allow the sequestering to the intracellular membranes. Myristoylation may mediate targeting to the intracellular non-Golgi membranes and palmitoylation may mediate the targeting to the Golgi membranes. Dual acylation is required to stabilize the interaction with Golgi membranes.,subunit:Homodimer.,tissue specificity:Expressed in all tissues and cell lines tested with the highest level of abundance in testis.,

Gene Name: PSKH1

Protein Name: Serine/threonine-protein kinase H1

Molekulargewicht: 48 kDa

Gen-ID: 5681

OMIM: 177015

UniProt: P11801