SENP6 Antikörper (AA 1042-1091)

Produktnummer ABIN1533440

Der Kaninchen Polyklonal anti-SENP6 Antikörper (ABIN1533440) detektiert spezifisch SENP6 in ELISA, IHC und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für SENP6 Antikörper (AA 1042-1091) (ABIN1533440)

Target: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SENP6 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-SENP6 Antikörper

Bindungsspezifität: AA 1042-1091

Verwendungszweck: SENP6 Antibody

Spezifität: SENP6 Polyclonal Antibody detects endogenous levels of SENP6 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human SENP6. AA range:1042-1091

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu SENP6

Target: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Andere Bezeichnung: SENP6

Hintergrund:

Synonyms: SENP6, KIAA0797, SSP1, SUSP1, FKSG6, Sentrin-specific protease 6, SUMO-1-specific protease 1, Sentrin/SUMO-specific protease SENP6

Background: Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1, MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA, MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for

Gene Name: SENP6

Protein Name: Sentrin-specific protease 6

Molekulargewicht: 126 kDa

Gen-ID: 26054

OMIM: 605003

UniProt: Q9GZR1