TIMP2 Antikörper (AA 21-70)

Produktnummer ABIN1533420

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch TIMP2 in WB, IHC, ELISA und IF. Es zeigt Reaktivität gegenüber Proben von Human, Ratte und Maus. Es wurde in 2+ Publikationen zitiert.

Kurzübersicht für TIMP2 Antikörper (AA 21-70) (ABIN1533420)

Target: TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TIMP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-TIMP2 Antikörper

Bindungsspezifität: AA 21-70

Verwendungszweck: TIMP-2 Antibody

Spezifität: TIMP-2 Polyclonal Antibody detects endogenous levels of TIMP-2 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human TIMP2. AA range:21-70

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Referenzen für anti-TIMP2 Antikörper (ABIN1533420)

Nishihara, Remacle, Angert, Shubayev, Shiryaev, Liu, Dolkas, Chernov, Strongin, Shubayev: "Matrix metalloproteinase-14 both sheds cell surface neuronal glial antigen 2 (NG2) proteoglycan on macrophages and governs the response to peripheral nerve injury." in: The Journal of biological chemistry, Vol. 290, Issue 6, pp. 3693-707, (2015) (PubMed).

Hu, Cai, Hu, Patel, Bard, Jamison, Coling: "Metalloproteinases and their associated genes contribute to the functional integrity and noise-induced damage in the cochlear sensory epithelium." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 43, pp. 14927-41, (2012) (PubMed).

Details zu TIMP2

Target: TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

Andere Bezeichnung: TIMP2

Hintergrund:

Synonyms: TIMP2, Metalloproteinase inhibitor 2, CSC-21K, Tissue inhibitor of metalloproteinases 2, TIMP-2

Background: This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008],

Gene Name: TIMP2

Protein Name: Metalloproteinase inhibitor 2

Molekulargewicht: 24 kDa

Gen-ID: 7077

OMIM: 188825

UniProt: P16035

Pathways: cAMP Metabolic Process