Factor VIII Antikörper (AA 2161-2210)

Produktnummer ABIN1533268

Der Kaninchen Polyklonal anti-Factor VIII Antikörper (ABIN1533268) detektiert spezifisch Factor VIII in WB, IHC, ELISA und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für Factor VIII Antikörper (AA 2161-2210) (ABIN1533268)

Target: Factor VIII (F8) (Coagulation Factor VIII (F8))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Factor VIII Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-Factor VIII Antikörper

Bindungsspezifität: AA 2161-2210

Verwendungszweck: Factor VIII Antibody

Spezifität: Factor VIII Polyclonal Antibody detects endogenous levels of Factor VIII protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human Factor VIII. AA range:2161-2210

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu Factor VIII

Target: Factor VIII (F8) (Coagulation Factor VIII (F8))

Andere Bezeichnung: Factor VIII

Hintergrund:

Synonyms: F8, F8C, Coagulation factor VIII, Antihemophilic factor, AHF, Procoagulant component

Background: This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation, factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008],

Gene Name: F8

Protein Name: Coagulation factor VIII

Molekulargewicht: 267 kDa

Gen-ID: 2157

OMIM: 306700

UniProt: P00451