TLK1 Antikörper (AA 730-779)

Produktnummer ABIN1532489

Der Kaninchen Polyklonal anti-TLK1 Antikörper (ABIN1532489) detektiert spezifisch TLK1 in ELISA und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für TLK1 Antikörper (AA 730-779) (ABIN1532489)

Target: TLK1 (Tousled-Like Kinase 1 (TLK1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TLK1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF)

Produktdetails anti-TLK1 Antikörper

Bindungsspezifität: AA 730-779

Verwendungszweck: TLK1 Antibody

Spezifität: TLK1 Polyclonal Antibody detects endogenous levels of TLK1 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human TLK1. AA range:730-779

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu TLK1

Target: TLK1 (Tousled-Like Kinase 1 (TLK1))

Andere Bezeichnung: TLK1

Hintergrund:

Synonyms: TLK1, KIAA0137, Serine/threonine-protein kinase tousled-like 1, PKU-beta, Tousled-like kinase 1

Background: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Cell-cycle regulated, maximal activity in S-phase. Inactivated by phosphorylation at Ser-743, potentially by CHK1.,function:Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by faciliting the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subunit:Heterodimerizes with TLK2. Interacts with ASF1A and ASF1B.,tissue specificity:Widely expressed. Present in fetal placenta, liver, kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined.,

Gene Name: TLK1

Protein Name: Serine/threonine-protein kinase tousled-like 1

Molekulargewicht: 86 kDa

Gen-ID: 9874

OMIM: 608438

UniProt: Q9UKI8