PRKACA/PRKACB Antikörper (AA 166-215)

Produktnummer ABIN1532391

Der Kaninchen Polyklonal anti-PRKACA/PRKACB Antikörper wird verwendet zum Nachweis von PRKACA/PRKACB in Proben von Human, Maus, Ratte und Schwein. Er wurde validiert für WB, IHC, IF und ELISA.

Kurzübersicht für PRKACA/PRKACB Antikörper (AA 166-215) (ABIN1532391)

Target: PRKACA/PRKACB (PRKACA/B) (Protein Kinase A, alpha/beta (PRKACA/B))

Reaktivität: Human, Maus, Ratte, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRKACA/PRKACB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA

Produktdetails anti-PRKACA/PRKACB Antikörper

Bindungsspezifität: AA 166-215

Verwendungszweck: PKAα/β/γ cat Antibody

Spezifität: PKAα/β/γ cat Polyclonal Antibody detects endogenous levels of PKAα/β/γ cat protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human PKA alpha/beta CAT. AA range:166-215

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu PRKACA/PRKACB

Target: PRKACA/PRKACB (PRKACA/B) (Protein Kinase A, alpha/beta (PRKACA/B))

Andere Bezeichnung: PKA alpha/beta CAT

Hintergrund:

Synonyms: PRKACA; PKACA; cAMP-dependent protein kinase catalytic subunit alpha; PKA C-alpha; PRKACB; cAMP-dependent protein kinase catalytic subunit beta; PKA C-beta; PRKACG; cAMP-dependent protein kinase catalytic subunit gamma; PKA C-gamma

Background: This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Altern

Gene Name: PRKACA/PRKACB

Protein Name: cAMP-dependent protein kinase catalytic subunit alpha/beta

Molekulargewicht: 40 kDa

Gen-ID: 5566, 5567

OMIM: 601639

UniProt: P17612