Doublecortin Antikörper (pSer376)

Produktnummer ABIN1532140

Der Kaninchen Polyklonal anti-Doublecortin Antikörper wird verwendet zum Nachweis von Doublecortin in Proben von Human, Maus, Ratte und Schwein. Er wurde validiert für ELISA, IHC und IF.

Kurzübersicht für Doublecortin Antikörper (pSer376) (ABIN1532140)

Target: Doublecortin (DCX)

Reaktivität: Human, Maus, Ratte, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Doublecortin Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-Doublecortin Antikörper

Bindungsspezifität: AA 330-365, pSer376

Verwendungszweck: Doublecortin (phospho Ser339) Antibody

Spezifität: Phospho-Doublecortin (S339) Polyclonal Antibody detects endogenous levels of Doublecortin protein only when phosphorylated at S339.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human Doublecortin around the phosphorylation site of Ser376. AA range:330-365

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu Doublecortin

Target: Doublecortin (DCX)

Andere Bezeichnung: Doublecortin

Hintergrund:

Synonyms: DCX; DBCN; LISX; Neuronal migration protein doublecortin; Doublin; Lissencephalin-X; Lis-X

Background: This gene encodes a member of the doublecortin family.The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain&quo

Gene Name: DCX

Protein Name: Neuronal migration protein doublecortin

Molekulargewicht: 44 kDa

Gen-ID: 1641

OMIM: 300067

UniProt: O43602