S1PR1 Antikörper (pSer1, pThr236)

Produktnummer ABIN1531727

Der Kaninchen Polyklonal anti-S1PR1 Antikörper wird verwendet zum Nachweis von S1PR1 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, ELISA und IF.

Kurzübersicht für S1PR1 Antikörper (pSer1, pThr236) (ABIN1531727)

Target: S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser S1PR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-S1PR1 Antikörper

Bindungsspezifität: AA 206-255, pSer1, pThr236

Verwendungszweck: EDG-1 (phospho Thr236) Antibody

Spezifität: Phospho-EDG-1 (T236) Polyclonal Antibody detects endogenous levels of EDG-1 protein only when phosphorylated at T236.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human S1P Receptor EDG1 around the phosphorylation site of Thr236. AA range:206-255

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-2000 IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu S1PR1

Target: S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))

Andere Bezeichnung: S1P Receptor EDG1

Hintergrund:

Synonyms: S1PR1, CHEDG1, EDG1, Sphingosine 1-phosphate receptor 1, S1P receptor 1, S1P1, Endothelial differentiation G-protein coupled receptor 1, Sphingosine 1-phosphate receptor Edg-1, S1P receptor Edg-1, CD antigen CD363

Background: The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],

Gene Name: S1PR1

Protein Name: Sphingosine 1-phosphate receptor 1

Molekulargewicht: 42 kDa

Gen-ID: 1901

OMIM: 601974

UniProt: P21453

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2