Integrin beta 4 Antikörper (pTyr1510)

Produktnummer ABIN1531676

Der Kaninchen Polyklonal anti-Integrin beta 4 Antikörper wird verwendet zum Nachweis von Integrin beta 4 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, IHC, ELISA und IF.

Kurzübersicht für Integrin beta 4 Antikörper (pTyr1510) (ABIN1531676)

Target: Integrin beta 4 (ITGB4)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Integrin beta 4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-Integrin beta 4 Antikörper

Bindungsspezifität: AA 1481-1530, pTyr1510

Verwendungszweck: Integrin β4 (phospho Tyr1510) Antibody

Spezifität: Phospho-Integrin β4 (Y1510) Polyclonal Antibody detects endogenous levels of Integrin β4 protein only when phosphorylated at Y1510.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human ITGB4 around the phosphorylation site of Tyr1510. AA range:1481-1530

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu Integrin beta 4

Target: Integrin beta 4 (ITGB4)

Andere Bezeichnung: ITGB4

Hintergrund:

Synonyms: ITGB4, Integrin beta-4, GP150, CD antigen CD104

Background: Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth.This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Gene Name: ITGB4

Protein Name: Integrin beta-4

Molekulargewicht: 202 kDa

Gen-ID: 3691

OMIM: 147557

UniProt: P16144

Pathways: Integrin Complex