Synuclein Antikörper (pSer129)

Produktnummer ABIN1531399

Der Kaninchen Polyklonal anti-Synuclein Antikörper wird verwendet zum Nachweis von Synuclein in Proben von Human, Maus und Ratte. Er wurde validiert für WB, IHC, ELISA und IF.

Kurzübersicht für Synuclein Antikörper (pSer129) (ABIN1531399)

Target: Synuclein (SYU)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Synuclein Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-Synuclein Antikörper

Bindungsspezifität: AA 91-140, pSer129

Verwendungszweck: Synuclein-α (phospho Ser129) Antibody

Spezifität: Phospho-Synuclein-α (S129) Polyclonal Antibody detects endogenous levels of Synuclein-α protein only when phosphorylated at S129.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human Synuclein around the phosphorylation site of Ser129. AA range:91-140

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu Synuclein

Target: Synuclein (SYU)

Andere Bezeichnung: Synuclein

Hintergrund:

Synonyms: SNCA; NACP; PARK1; Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP

Background: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016],

Gene Name: SNCA

Protein Name: Alpha-synuclein

Molekulargewicht: 14 kDa

Gen-ID: 6622

OMIM: 127750

UniProt: P37840