Phospholamban Antikörper (pSer16, pThr17)

Produktnummer ABIN1531373

Der Kaninchen Polyklonal anti-Phospholamban Antikörper (ABIN1531373) detektiert spezifisch Phospholamban in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte und Maus.

Kurzübersicht für Phospholamban Antikörper (pSer16, pThr17) (ABIN1531373)

Target: Phospholamban (PLN)

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Phospholamban Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Phospholamban Antikörper

Bindungsspezifität: AA 1-50, pSer16, pThr17

Verwendungszweck: PLB (phospho Ser16/T17) Antibody

Spezifität: Phospho-PLB (S16/T17) Polyclonal Antibody detects endogenous levels of PLB protein only when phosphorylated at S16/T17.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human PLB around the phosphorylation site of Ser16 and Thr17. AA range:1-50

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-2000,IHC 1:50-300

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu Phospholamban

Target: Phospholamban (PLN)

Andere Bezeichnung: PLB

Hintergrund:

Synonyms: PLN, PLB, Cardiac phospholamban, PLB

Background: The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016],

Gene Name: PLN

Protein Name: Cardiac phospholamban

Molekulargewicht: 6 kDa

Gen-ID: 5350

OMIM: 172405

UniProt: P26678

Pathways: Negative Regulation of Transporter Activity