Opioid Receptor (AA 341-390), (pSer375) Antikörper

Produktnummer ABIN1531191

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Opioid Receptor in WB, ELISA, IHC und IF. Es zeigt Reaktivität gegenüber Proben von Maus, Ratte und Human.

Kurzübersicht für Opioid Receptor (AA 341-390), (pSer375) Antikörper (ABIN1531191)

Target: Opioid Receptor

Reaktivität: Maus, Ratte, Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails

Bindungsspezifität: AA 341-390, pSer375

Verwendungszweck: MOR-1 (phospho Ser375) Antibody

Spezifität: Phospho-MOR-1 (S375) Polyclonal Antibody detects endogenous levels of MOR-1 protein only when phosphorylated at S375.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human Opioid Receptor around the phosphorylation site of Ser375. AA range:341-390

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Antigendetails

Target: Opioid Receptor

Hintergrund:

Synonyms: OPRM1; MOR1; Mu-type opioid receptor; M-OR-1; MOR-1; Mu opiate receptor; Mu opioid receptor; MOP; hMOP

Background: This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013],

Gene Name: OPRM1

Protein Name: Mu-type opioid receptor

Molekulargewicht: 44 kDa

Gen-ID: 4988

OMIM: 600018

UniProt: P35372