ANKRD2 Antikörper

Produktnummer ABIN1504147

Dieses Maus Monoklonal-Antikörper erkennt spezifisch ANKRD2 in WB und IHC (p). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für ANKRD2 Antikörper (ABIN1504147)

Target: ANKRD2 (Ankyrin Repeat Domain 2 (Stretch Responsive Muscle) (ANKRD2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ANKRD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: YAS11

Produktdetails anti-ANKRD2 Antikörper

Spezifität: This antibody reacts with ARPP (43 kDa).

Kreuzreaktivität (Details): Species reactivity (tested):Human (TE-1).
Does not react with Mouse (NIH/3T3).

Aufreinigung: Protein A agarose

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Konservierungsmittel: Without preservative

Details zu ANKRD2

Target: ANKRD2 (Ankyrin Repeat Domain 2 (Stretch Responsive Muscle) (ANKRD2))

Andere Bezeichnung: ANKRD2

Hintergrund: Ankyrin-repeat protein with a PEST motif and a proline-rich region (ARPP), also designated as Ankrd2, which isolated from a cDNA library of human esophageal carcinoma cell line (TE-1) is composed of 333 amino acids and contains four ankyrin-like repeat motifs in its middle portion, a PEST-like sequence and a lysine-rich sequence in the N-terminal region, and a proline-rich region in the C-terminal region. ARPP is homologous to CARP, cardiac ankyrin repeat protein (52 % identical), which is a nuclear protein and is involved in the regulation of the transcription of MLC-2s in cardiomyogenesis. In the immunohistochemical analysis of paraffin embedded sections, ARPP is found to express at a high level in almost all rhabdomyosarcomas. On the other hand in normal tissues, ARPP preferentially expresses in skeletal and cardiac muscle. Furthermore ARPP expresses in part of the distal tubule of the kidney and also expresses specifically in renal oncocytoma but barely detectable in conventional renal cell carcinoma. ARPP may have potential use as a marker for distinguishing renal oncocytoma from other renal cell carcinomas.Synonyms: ARPP, Ankyrin repeat domain-containing protein 2, Skeletal muscle ankyrin repeat protein

Gen-ID: 26287