VASH1 Antikörper (AA 261-310)

Produktnummer ABIN1452171

Der Kaninchen Polyklonal anti-VASH1 Antikörper (ABIN1452171) detektiert spezifisch VASH1 in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für VASH1 Antikörper (AA 261-310) (ABIN1452171)

Target: VASH1 (Vasohibin 1 (VASH1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VASH1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-VASH1 Antikörper

Bindungsspezifität: AA 261-310

Verwendungszweck: Vasohibin Antibody

Spezifität: Vasohibin Polyclonal Antibody detects endogenous levels of Vasohibin protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from human VASH1. AA range:261-310

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu VASH1

Target: VASH1 (Vasohibin 1 (VASH1))

Andere Bezeichnung: VASH1

Hintergrund:

Synonyms: VASH1, KIAA1036, VASH, Vasohibin-1

Background: caution:Although probably secreted, it lacks a canonical signal sequence.,function:Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. Acts in an autocrine manner. Inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activity.,induction:By VEGF.,PTM:2 major forms (42 and 36 kDa) and 2 minors (32 and 27 kDa) may be processed by proteolytic cleavage. The largest form (42 kDa) seems to be secreted and the other major form (63 kDa) seems to accumulate within the cells or pericellular milieu. Polypeptide consisting of Met-77 to Arg-318 may correspond to the 27 kDa form and that consisting of Met-77 to Val-365 may correspond to the 36 kDa form.,similarity:Belongs to the vasohibin family.,tissue specificity:Preferentially expressed in endothelial cells. Highly expressed in fetal organs. Expressed in brain and placenta, and at lower level in heart and kidney. Highly detected in microvessels endothelial cells of atherosclerotic lesions.,

Gene Name: VASH1

Protein Name: Vasohibin-1

Molekulargewicht: 40 kDa

Gen-ID: 22846

OMIM: 609011

UniProt: Q7L8A9