JDP2 Antikörper (pThr148)

Produktnummer ABIN1450491

Der Kaninchen Polyklonal anti-JDP2 Antikörper (ABIN1450491) detektiert spezifisch JDP2 in ELISA, IHC und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für JDP2 Antikörper (pThr148) (ABIN1450491)

Target: JDP2 (Jun Dimerization Protein 2 (JDP2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser JDP2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-JDP2 Antikörper

Bindungsspezifität: AA 114-163, pThr148

Verwendungszweck: JDP2 (phospho Thr148) Antibody

Spezifität: Phospho-JDP2 (T148) Polyclonal Antibody detects endogenous levels of JDP2 protein only when phosphorylated at T148.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from human JDP-2 around the phosphorylation site of Thr148. AA range:114-163

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu JDP2

Target: JDP2 (Jun Dimerization Protein 2 (JDP2))

Andere Bezeichnung: JDP-2

Hintergrund:

Synonyms: JDP2, Jun dimerization protein 2

Background: function:Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.,PTM:Phosphorylation of Thr-148 by MAPK8 in response to different stress conditions such as, UV irradiation, oxidatives stress and anisomycin treatments.,similarity:Belongs to the bZIP family. ATF subfamily.,similarity:Contains 1 bZIP domain.,subunit:Forms homodimer or heterodimer with JUN, JUNB, JUND, CEBPG and ATF2 thereby inhibiting transactivation by JUN, ATF2 and CEBPG (By similarity). Binds multiple DNA elements such as cAMP-response element (CRE) and TPA response element (TRE) either as homodimer or heterodimer.,

Gene Name: JDP2

Protein Name: Jun dimerization protein 2

Molekulargewicht: 18 kDa

Gen-ID: 122953

OMIM: 608657

UniProt: Q8WYK2

Pathways: Chromatin Binding